What Is Ketogenesis and What Are Ketone Bodies?

Last Updated on March 4, 2021 by Michael Joseph

The Structure of Ketone Bodies: Acetone, Acetoacetate and 2-Hydroxybutyric Acid.With heavy coverage in the media, low carb and ketogenic diets have become increasingly popular over recent years.

But what do all these different terms like ketogenesis and ketone bodies actually mean?

This article provides a short summary of what the ketogenesis pathway is and what ketone bodies do.

What is Ketogenesis?

Ketogenesis is a biochemical process through which the body breaks down fatty acids into ketone bodies (1).

Synthesis of ketone bodies through ketogenesis kicks in during times of carbohydrate restriction or periods of fasting. When carbohydrate is in short supply, ketones become the default energy source for our body (1).

Ketogenesis may also occur at slightly higher levels of carbohydrate intake. When ketogenesis takes place, the body produces ketone bodies as an alternative fuel to glucose.

This physiological state is known as ‘nutritional ketosis’.

There are various methods people can use to test if they are “in ketosis”.

It is also worth noting that ‘ketosis’ and ‘ketoacidosis’ are very different things. For more on this topic, see this guide to ketogenic diets and ketoacidosis.

Key Point: Ketogenesis is a biological pathway that breaks fats down into a form of energy called ketone bodies.

What Are Ketone Bodies?

Ketone bodies are water-soluble compounds that act as a form of energy in the body.

There are three major types of ketone body (2):

  • Acetoacetate
  • Beta-hydroxybutyrate
  • Acetone (a compound created through the breakdown of acetoacetate)

As an alternative energy source to glucose, these ketones can also satisfy our body’s energy requirements.

However, unlike glucose, ketone bodies have no impact on blood sugar or insulin levels.

Key Point: Ketone bodies are an alternative source of fuel that the body can use for energy. Ketones are produced from the breakdown of fat.

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10 thoughts on “What Is Ketogenesis and What Are Ketone Bodies?”

  1. Thank you for the insightful information. However, you only listed the positive effects of ketone body. Are there any negative effects?

    Reply
    • Hi Ima,

      Basically, the nutrient profile is a bigger indicator of how healthy a food is than the type of macronutrient (carbs/fat) it contains.
      For example, coconut oil and butter… they are fine. Good for cooking, and they make our food tastier. But if huge amounts of calories are coming from them, then we are displacing more nutritious options that are full of vitamins and minerals.

      Also, various fried foods can be “keto,” but they may be using unhealthy vegetable oils, so they still wouldn’t be supportive of good health.

      Reply
  2. I am diabetic and i started to take keto diet a month and four ago. My HBA1C dropped from 7.0 yo 5.9 in this short time. But my lipids are sky rocketing. Triglycerides Jumped to 352 from 200. Total cholesterol jumped ftom 185 to 412. But isn’t this contrary to what you said like it will improve triglycerides to HDL ratio? Of course my HDL went upto 46 frm 34. But still the ratio moved to the wrong side. Coild you please throw some light on this?

    Reply

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